Meet Plenity—an FDA‑cleared weight management tool

● In Stock $98 for a four-week supply $1.75 per meal

  • In a clinical study, nearly 6 out of 10 people who took Plenity lost at least 5% of their body weight. Their average weight loss was 10% (about 22 pounds).
  • Complete an online visit with a healthcare professional and, if prescribed, get Plenity shipped to your front door.
  • Plenity® is indicated to aid weight management in adults with excess weight or obesity, Body Mass Index (BMI) of 25 to 40 kg/m2, when used in conjunction with diet and exercise.

How it works.

Plenity, made from naturally derived building blocks, is a capsule that helps you feel full, eat less, and lose weight. Plenity absorbs the water you drink with it and mixes with the food you eat. And as you continue to use it, you feel fuller throughout the day.

Online visit

You’ll start the visit by answering general health questions and sharing your medical history.

Hear back in 24 hours

A healthcare professional will review your visit and decide if Plenity is right for you.

Plenity, delivered

If prescribed, you’ll get contactless, discreet, door-to-door delivery with free 2-day shipping.


The results.

In a six-month clinical study (GLOW), Plenity responders (nearly 60% of people) lost 22 pounds, on average.

Learn more about Gelesis loss of weight (GLOW) clinical study

In the GLOW study, nearly 6 out of 10 people who took Plenity lost at least 5% of their body weight. Their average weight loss was 10% (about 22 pounds). Plenity or placebo was given to 436 adults who were overweight or had obesity, with and without type 2 diabetes, over 24 weeks in conjunction with diet and exercise. The study was designed to measure: whether at least 35% of individuals receiving Plenity lost 5% of their body weight, whether individuals receiving Plenity lost 3% more of their body weight than individuals receiving placebo. Individuals on Plenity lost on average 6% vs individuals on placebo, who lost on average 4%. Though the Plenity group achieved statistically superior weight loss compared to placebo, it did not meet the predefined super-superiority margin of 3% to successfully meet this co-primary endpoint.

You’ve got questions. We’ve got answers.

Since Plenity is a different weight management tool—we encourage you to explore a few important questions and find out if Plenity is right for you.

How safe is it?

Plenity has been shown in a clinical study to have a proven safety profile and is as well-tolerated as a placebo (a capsule with inactive ingredients).

Is it natural?

Plenity is made from two naturally derived building blocks—cellulose (found in fruits and vegetables) and citric acid (naturally found in citrus fruits).

How long can I take it?

Plenity is not habit-forming or addictive and there is no restriction on how long it can be used.

Are there any side effects?

In clinical studies there was no difference in overall side effects compared to placebo. The most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence.

Frequently asked questions

Have questions about Plenity? We've got answers.
Here are a few of our top FAQs.

When will I begin to lose weight?

Weight loss is a gradual process and every experience is different. In clinical studies, most people taking Plenity with diet and exercise had excess body weight loss over time that was significant at 4 weeks.

Do I need to be on a specific diet or exercise regimen when taking Plenity?

Having a reduced calorie diet with 30 minutes of daily physical activity is part of a healthy lifestyle. Plenity can work with any diet or nutrition plan and since Plenity makes you feel fuller, it can help you eat less.

How does Plenity work?

When Plenity is combined with water, small Plenity hydrogel particles are formed. These hydrated hydrogel particles do not clump together, rather they mix with food and promote a sense of fullness.


Check out
Plenity in action

See how Plenity is different from diets
and can help make you feel fuller.

Important Safety Information

  • Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity.
  • To avoid impact on the absorption of medications:
    • For all medications that should be taken with food, take them after starting a meal.
    • For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician.
  • The overall incidence of side effects with Plenity was no different than placebo. The most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence.
  • Contact a doctor right away if problems occur. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor.

Rx Only. For the safe and proper use of Plenity or more information, talk to a healthcare professional, read the Patient Instructions for Use, or call 1-844-PLENITY.